Peer-Reviewed Publication
Fluids Barriers CNS2026;23(1)April 9, 2026Journal Article
Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus.
Andrius Penkauskas1, Eemeli Kuukkanen2, Anssi Lipponen3, Juhana Hakumäki4, Juha Koikkalainen5, Jyrki Lotjonen5, Lauri Erkkilä4, Jussi Tohka6, Pauli Miettinen7, Ville Leinonen2
1School of Computing, University of Eastern Finland, Kuopio, 70211, Finland. andrius.penkauskas@gmail.com.
2Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211, Finland.
3Institute of Biomedicine, University of Eastern Finland, Kuopio, 70211, Finland.
4Institute of Clinical Medicine-Radiology, University of Eastern Finland, Kuopio, 70211, Finland.
5Combinostics Ltd., Tampere, 33100, Finland.
6A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, 70211, Finland.
7School of Computing, University of Eastern Finland, Kuopio, 70211, Finland.
Abstract
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is characterized by a clinical triad of symptoms: abnormal gait, memory problems, and urinary incontinence. Neuroimaging plays a crucial role in diagnosing iNPH. However, current radiological markers, though indicative, are not definitive, suggesting the limited capacity of these indices to capture mechanisms associated with iNPH and the…
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