Health AI Central
Peer-Reviewed Publication
J Neuroinflammation2026;23(1)April 10, 2026Journal Article

Network-based disease fingerprinting with neuroinflammation PET imaging.

Leonardo Barzon1, Lucia Maccioni2, Michelle Carranza Mellana3, Julia J Schubert4, Ludovica Brusaferri5,6, Oliver Cousins4, Ivana Rosenzweig4, Yuya Mizuno4,7,8, Tiago Reis Marques9, Neil A Harrison10, Tim Fryer11, Edward T Bullmore12, Valeria Mondelli4, Carmine Pariante4, David Sharp13, Gregory Scott13, Joana B Pereira14, Oliver Howes4,15, Vesna Sossi16, Benedetta Bodini3, Bruno Stankoff3, Marco L Loggia5, Federico E Turkheimer4, Mattia Veronese17,18
1Department of Information Engineering, University of Padova, Via Gradenigo 6/B, Padua, 35122, Italy. leonardo.barzon.1@phd.unipd.it.
2Department of Information Engineering, University of Padova, Via Gradenigo 6/B, Padua, 35122, Italy.
3Paris Brain Institute, ICM, CNRS, Inserm, Sorbonne Université, Paris, Sorbonne, France.
4Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
5Departments of Radiology and Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
6Computer Science and Informatics, School of Engineering, London South Bank University, London, UK.
7South London and Maudsley NHS Foundation Trust, London, UK.
8Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
9Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital, Imperial College London, London, UK.
10Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
11Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
12Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
13Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
14Division of Neuro, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
15Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK.
16Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.
17Department of Information Engineering, University of Padova, Via Gradenigo 6/B, Padua, 35122, Italy. mattia.veronese@unipd.it.
18Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. mattia.veronese@unipd.it.
PubMed PMC DOI PDF

Abstract

Neuroinflammation is a hallmark of numerous neurodegenerative, psychiatric, and chronic pain disorders and can be assessed in vivo with 18 kDa translocator protein (TSPO) positron emission tomography (PET). However, conventional quantification methods of TSPO PET are limited and often overlook the spatial relationships between regional signals. The application of network-based approaches to TSPO P…

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