CEST-MRI assessment of locally advanced pMMR rectal cancer for prediction of immune activation status following radiotherapy.

Ziwei Jin^1,2,3, Lan Zhang^1,2,3, Chuansheng Zheng^1,2,3, Fan Yang^1,2,3, Na Hao^1,2,3, Liza Mao^1,2,3, Bin Chi^1,2,3, Yuan Liu^1,2,3, Peng Sun⁴, Ning Zheng⁵, Haihong Wang^6,7,8, Zhenyu Lin^9,10,11, Xin Li^12,13,14

¹Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

²Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan, China.

³Hubei Key Laboratory of Molecular Imaging, Wuhan, China.

⁴Institute of Research and Clinical Innovations, Neusoft Medical Systems Co., Ltd., Shenyang, China.

⁵Clinical & Technical Support, Philips Healthcare, Wuhan, China.

⁶Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

⁷Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

⁸Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, China.

⁹Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. whxhlzy@hust.edu.cn.

¹⁰Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. whxhlzy@hust.edu.cn.

¹¹Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, China. whxhlzy@hust.edu.cn.

¹²Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lxwsry2014@163.com.

¹³Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan, China. lxwsry2014@163.com.

¹⁴Hubei Key Laboratory of Molecular Imaging, Wuhan, China. lxwsry2014@163.com.

PubMed DOI

Abstract

OBJECTIVES: To evaluate whether chemical exchange saturation transfer MRI (CEST-MRI) enables early prediction of treatment response to subsequent immunochemotherapy following radiotherapy in patients with proficient mismatch repair (pMMR) locally advanced rectal cancer (LARC). MATERIALS AND METHODS: In this prospective single-center study, consecutive pMMR LARC patients, who underwent short-cours…

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Mentioned Companies

Neusoft Medical Systems Co.
affiliation

Other Funding

the National Key Research and Development Program of China(2024YFE0217700)
the Joint Research projects supported by the National Natural Science Foundation of China and the Research Grants Council of Hong Kong(6201101073)

MeSH Terms

Humans0Rectal Neoplasms*Male0Magnetic Resonance Imaging*Female0Middle Aged0Prospective Studies0Pathologic Complete Response0Treatment Outcome0Neoadjuvant Therapy0Aged0

Keywords

Chemical exchange saturation transferRadiotherapyRectal cancerTumor metabolismpH assessment

Article Info

PMID: 41935245
DOI: 10.1007/s00330-026-12502-x
Received: November 3, 2025
Accepted: March 11, 2026

How to Cite

Jin Z et al. CEST-MRI assessment of locally advanced pMMR rectal cancer for prediction of immune activation status following radiotherapy. Eur Radiol2026;36(8):6788-6797. doi:10.1007/s00330-026-12502-x

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