Advancing aortic stenosis assessment: Validation of fluid-structure interaction models against 4D flow MRI data.

Alberto Zingaro¹, Irmantas Burba¹, David Oks¹, Mauro Fontana¹, Cristóbal Samaniego², Micha Bischofberger³, Bart de Boeck⁴, Andre Douverny³, Özge Karakas³, Stefan Toggweiler⁴, Dabit Arzamendi-Aizpurua^5,6, Utku Gülan³, Mariano Vázquez^1,2

¹ELEM Biotech, Barcelona, Catalonia, Spain.

²Barcelona Supercomputing Center, Barcelona, Catalonia, Spain.

³Hi-D Imaging, Winterthur, Zurich, Switzerland.

⁴Lucerne Cantonal Hospital (Luzerner Kantonsspital), Luzern, Switzerland.

⁵Cardiology Department, Hospital de la Santa Creu i Sant Pau., Barcelona, Catalonia, Spain.

⁶Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

PubMed DOI

Abstract

Systematic in vivo validations of computational models of the aortic valve (AV) remain scarce, despite successful validation against in vitro data. Utilizing a combination of computed tomography and 4D flow magnetic resonance imaging data, we developed patient-specific fluid-structure interaction models of the AV immersed in the aorta for five patients in the pre-transcatheter AV replacement confi…

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