Topical delivery of Mir-497 using cationized gelatin/sodium alginate coacervates for diabetic wound healing.

Eunmi Ban¹, Youngun Yu¹, Yeojin Kim^2,3, Jeil Lee¹, Seung-Hoi Koo³, Jinyoung Park^2,4, Aeri Kim¹

¹College of Pharmacy, CHA University, Gyeonggi-do, Republic of Korea.

²Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea.

³Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

⁴Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul, Republic of Korea.

PubMed DOI

Abstract

MicroRNA (miRNA)-based therapeutics are promising for chronic inflammatory diseases, yet their clinical translation is limited by poor stability, inefficient intracellular delivery, and safety concerns. Previously, we reported in vitro anti-inflammatory activity of miR-497 encapsulated in coacervate-based delivery platform composed of cationized gelatin (CG) and sodium alginate (SA). In the presen…

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