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Peer-Reviewed Publication
Brain Struct Funct2026;231(3)March 26, 2026Journal Article

Longitudinal visualization tools for advanced characterization of multiple sclerosis lesions using diffusion MRI and magnetization transfer imaging metrics.

Erick Hernandez-Gutierrez1, Ricardo Coronado-Leija2, Manon Edde3,4, François Rheault3, Matthieu Dumont5, Jean-Christophe Houde5, Muhamed Barakovic6, Stefano Magon6, Alonso Ramirez-Manzanares7, Maxime Descoteaux3,5
1Sherbrooke Connectivity Imaging Lab (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada. erick.hernandez.gutierrez@usherbrooke.ca.
2New York University School of Medicine (NYU), New York, NY, USA.
3Sherbrooke Connectivity Imaging Lab (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada.
4StoP-AD Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
5Imeka Solutions Inc., Sherbrooke, QC, Canada.
6Pharma Research and Early Development, Neuroscience and Rare Diseases Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
7Computer Science Department, Centro de Investigación en Matemáticas (CIMAT), Guanajuato, GT, Mexico.

Abstract

Understanding how white matter microstructure supports functional network organization requires tools capable of characterizing tissue properties across multiple complementary metrics and spatial scales simultaneously. White matter pathology disrupts the relationship between microstructural tissue organization and network-level function in spatial and temporal patterns that reveal fundamental prin…

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