Health AI Central
Peer-Reviewed Publication
Am J Hum Genet2026;113(4):767-781.April 2, 2026Journal Article

Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.

Paige E Haffener1, Arwa Z Al-Riyami2, Shoaib Al-Zadjali3, George B J Busby4, Sulaiman Al-Mahdhuri5, Mohammed Al-Rawahi6, Saif Al-Hosni7, Ali Al-Marhoobi6, Ammar Al-Sheriyani8, Ellen M Leffler9
1Department of Human Genetics, the University of Utah School of Medicine, Salt Lake City, UT, USA.
2Department of Hematology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman; Department of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: arwa@squ.edu.om.
3Sultan Qaboos Comprehensive Cancer Center, University Medical City, Muscat, Oman.
4Allelica, Inc., New York, NY, USA.
5National Records & Archives Authority, Muscat, Oman.
6Department of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
7Department of Hematology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.
8Royal Oman Police Hospital, Muscat, Oman.
9Department of Human Genetics, the University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: leffler@genetics.utah.edu.
PubMed PMC DOI PDF

Abstract

Malaria in humans is largely caused by two divergent species of Plasmodium parasites, P. vivax and P. falciparum, both of which have driven the spread of protective alleles in human populations. Notably, an erythrocyte-specific Duffy null allele (FyES) confers resistance to P. vivax malaria and has been identified as a target of strong, recent positive selection in multiple African-admixed populat…

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