Keratin 7 immunohistochemistry reveals patterns of cell populations in liver biopsies from patients with MASLD.

Leana Ducor¹, Montserrat Fraga², Rita Manco³, Elise Mdawar-Bailly², Joana Vieira², Christine Sempoux¹, Pierre Moulin^4,5

¹Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

²Service of Gastroenterology and Hepatology, Lausanne University Hospital, Lausanne, Switzerland.

³Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Louvain-la-Neuve, Belgium.

⁴Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland Pierre.moulin@deciphex.com.

⁵Deciphex Ltd, Dublin, Ireland.

PubMed DOI

Abstract

AIMS: Metabolic-associated steatotic liver disease (MASLD), which encompasses metabolic associated steatotic liver (MASL) and metabolic-associated steatohepatitis (MASH), is the most common chronic liver disorder worldwide. Fibrosis stage remains the most dependable histological predictor of prognosis; however, routine stains do not fully capture regenerative and injury-related processes. Keratin…

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