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Peer-Reviewed Publication
Nat Med2026;32(5):1717-1725.May 1, 2026Journal Article

A cognitive layer architecture to support large-language model performance in psychotherapy interactions.

Max Rollwage1, Jessica McFadyen2, Keno Juchems2, Annamaria Balogh2, Sashank Pisupati2, Margareta-Theodora Mircea2, Tobias U Hauser2,3,4,5, George Prichard2, Ross Harper2
1Limbic, London, UK. rollwagm@gmail.com.
2Limbic, London, UK.
3Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
4Department of Psychiatry and Psychotherapy, Medical School and University Hospital, Eberhard Karls University of Tubingen, Tubingen, Germany.
5German Center for Mental Health (DZPG), Tubingen, Germany.

Abstract

Clinician-patient conversations form the cornerstone of mental healthcare. Large language models (LLMs) could hold promise for this domain but their effectiveness in patient-facing interactions remains largely unproven. Here we introduce a cognitive layer architecture that enhances general-purpose LLMs with specialized clinical psychotherapeutic reasoning capabilities. In a randomized, double-blin…

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