Guiding Preventive Care Strategies for Patients With Atherosclerotic Plaque on Coronary CTA: Primary Outcomes of the DECIDE Registry.

Sarah Rinehart¹, Ron Blankstein², Cian P McCarthy³, James L Januzzi³, Markus Scherer⁴, Wesley T O'Neal⁵, Philip Green⁶, Joseph Puma⁶, Frank Corrigan⁷, Jaydip Datta⁸, Jens Eichhorn⁴, Thomas Stuckey⁵, Omar Khalique⁹, Ziad Ali⁹, Nicholas Ng¹⁰, Whitney Huey¹⁰, Sarah Mullen¹⁰, Campbell Rogers¹⁰, Leslee J Shaw¹¹,

¹Charleston Area Medical Center, Charleston, West Virginia, USA. Electronic address: sarah.rinehart@vandaliahealth.org.

²Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

³Heart and Vascular Institute, Massachusetts General Brigham and Harvard Medical School, Boston, Massachusetts, USA; Baim Institute for Clinical Research, Boston, Massachusetts, USA.

⁴Atrium Health Sanger Heart and Vascular Institute, Charlotte, North Carolina, USA.

⁵Cone Heart and Vascular Center, Greensboro, North Carolina, USA.

⁶Sorin Medical, New York, New York, USA.

⁷Wellstar Medical Group, Marietta, Georgia, USA.

⁸Quantum Radiology, Marietta, Georgia, USA.

⁹Saint Francis Hospital and Heart Center, Roslyn, New York, USA.

¹⁰Heartflow, Inc, Mountain View, California, USA.

¹¹Blavatnik Family Research Institute, Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

PubMed DOI

Abstract

BACKGROUND: Artificial intelligence-enabled coronary plaque analysis (AI-CPA) has been shown to improve cardiovascular risk prediction. However, little is known about how these measures influence management. OBJECTIVES: This study sought to define changes in management guided by AI-CPA as compared with management guided by measures of nonobstructive and obstructive stenosis on coronary computed t…

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Mentioned Companies

HEARTFLOW
affiliation

MeSH Terms

Humans0Registries0Female0Plaque, Atherosclerotic*Coronary Angiography*Predictive Value of Tests0Computed Tomography Angiography*Middle Aged0Coronary Artery Disease*Male0Prospective Studies0Time Factors0Aged0Coronary Stenosis*Coronary Vessels*Risk Factors0Clinical Relevance0Clinical Decision-Making0Intelligent Systems0Severity of Illness Index0Treatment Outcome0

Keywords

atherosclerotic plaquecoronary CTAimplementationplaqueprevention

Article Info

PMID: 41817483
DOI: 10.1016/j.jcmg.2026.01.014
Received: August 29, 2025
Accepted: January 13, 2026

How to Cite

Rinehart S et al. Guiding Preventive Care Strategies for Patients With Atherosclerotic Plaque on Coronary CTA: Primary Outcomes of the DECIDE Registry. JACC Cardiovasc Imaging2026;19(6):706-716. doi:10.1016/j.jcmg.2026.01.014

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