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Stroke Vasc Interv Neurol2026;6(2):e002110.March 1, 2026Journal Article

Enhanced Detection of Acute Ischemic Stroke With Low-Field MRI.

Annabel Sorby-Adams1, Nandor K Pinter2,3, Amelia Demopoulos1, John Kirsch4, Vinay Jaikumar3, Olivia K Nelson5, Stephen Bacchi1, Jennifer Guo1, Blair A Parry5, Hailey Brigger6, Ian Johnson6, Adam de Havenon6, Gordon Sze7, Rafael O'Halloran8, John Pitts8, Vivien H Lee9, Keith W Muir10, Shahid M Nimjee11, Adnan Siddiqui3, Kathryn E Keenan12, Matthew S Rosen4, Juan Eugenio Iglesias4,13,14, Kevin N Sheth6, Joshua N Goldstein5, W Taylor Kimberly1
1Department of Neurology and the Center for Genomic Medicine (A.S.-A., A.D., S.B., J.G., W.T.K.), Massachusetts General Hospital and Harvard Medical School, Boston.
2Department of Radiology (N.K.P.), Jacobs School of Medicine & Biomedical Sciences, State University of New York at Buffalo, NY.
3Department of Neurosurgery (N.K.P., V.J., A.S.), Jacobs School of Medicine & Biomedical Sciences, State University of New York at Buffalo, NY.
4Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging (J.K., M.S.R., J.E.I.), Massachusetts General Hospital and Harvard Medical School, Boston.
5Department of Emergency Medicine (O.K.N., B.A.P., J.N.G.), Massachusetts General Hospital and Harvard Medical School, Boston.
6Department of Neurology, Center for Brain & Mind Health, Yale New Haven Hospital and Yale School of Medicine, CT (H.B., I.J., A.d.H., K.N.S.).
7Division of Neuroradiology, Department of Radiology and Biomedical Imaging, Yale New Haven Hospital and Yale University School of Medicine, CT (G.S.).
8Hyperfine Incorporated, Guilford, CT (R.O.H., J.P.).
9Department of Neurology (V.H.L.), The Ohio State University Wexner Medical Center, Columbus.
10School of Psychology and Neuroscience, University of Glasgow, United Kingdom (K.W.M.).
11Department of Neurological Surgery (S.M.N.), The Ohio State University Wexner Medical Center, Columbus.
12National Institute of Standards and Technology, Boulder, CO (K.E.K.).
13Hawkes Institute, University College London, United Kingdom (J.E.I.).
14Department of Electrical Engineering and Computer Science, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge (J.E.I.).
PubMed PMC DOI PDF

Abstract

BACKGROUND: Portable, low-field magnetic resonance imaging (MRI) has the potential to expand access to neuroimaging in environments where conventional MRI is limited. However, diffusion-weighted imaging at low magnetic field is challenged by a low signal-to-noise ratio and gradient strength, which may limit diagnostic confidence in acute ischemic stroke evaluation, particularly for very small stro…

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