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Child Abuse Negl2026;175107979.May 1, 2026Journal Article

Childhood trauma assessed using the childhood trauma questionnaire and its influence on pediatric mood disorders and self-harm: a systematic review and meta-analysis.

Silvia Montanari1, Tommaso Callovini2, Giovanni Bartolucci3, Ilaria Marcelli4, Gianna Autullo5, Alexia Koukopoulos6, Lorenzo Moccia7, Maria Pepe8, Georgios D Kotzalidis9, Marco Di Nicola10, Gabriele Sani11, Delfina Janiri12
1Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. Electronic address: silvia.montanari@unicatt.it.
2Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. Electronic address: t.callovini@gmail.com.
3Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. Electronic address: giovannibartolucci94@hotmail.it.
4Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. Electronic address: ilaria.marcelli.im@gmail.com.
5Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: gianna.autullo@gmail.com.
6Department of Life Science, Health, and Health Professions, Link Campus University, 00165, Rome, Italy. Electronic address: a.koukopoulos@unilink.it.
7Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy; Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: lorenzo.moccia@unicatt.it.
8Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy; Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: maria.pepe@unicatt.it.
9Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. Electronic address: giorgio.kotzalidis@gmail.com.
10Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy; Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: marco.dinicola@unicatt.it.
11Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy; Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: gabriele.sani@unicatt.it.
12Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy; Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. Electronic address: delfina.janiri@unicatt.it.
PubMed DOI

Abstract

BACKGROUND: Childhood trauma (CT) is a significant risk factor for mood disorders and self-harm behaviors in children and adolescents. The Childhood Trauma Questionnaire (CTQ) is the gold standard for quantifying early adversity dimensions. This systematic review and meta-analysis aims to synthesize evidence on the relationship between CT, as assessed by the CTQ, mood disorders, and non-suicidal s…

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