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Stroke2026;57(5):1325-1335.May 1, 2026Journal Article

Clinical Impact of Postrecanalization Hemorrhagic Transformation and Its Prediction Using Baseline Noncontrast CT.

Hee-Jung Ha1,2, Wi-Sun Ryu2, Leonard Sunwoo3, Myungjae Lee2, Kyusik Kang4, Jae Guk Kim5, Soo Joo Lee5, Jae-Kwan Cha6, Tai Hwan Park7, Jeong-Yoon Lee8, Kyungbok Lee8, Doo Hyuk Kwon9, Jun Lee9, Hong-Kyun Park10, Keun-Sik Hong10, Minwoo Lee11, Mi Sun Oh11, Kyung-Ho Yu11, Dong-Seok Gwak12, Dong-Eog Kim12, Hyunsoo Kim13, Joon-Tae Kim13, Joong-Goo Kim14, Jay Chol Choi14, Wook-Joo Kim15, Young Cheol Weon16, Jee Hyun Kwon15, Kyu Sun Yum17, Dong-Ick Shin17, Jeong-Ho Hong18, Sung-Il Sohn18, Sang-Hwa Lee19, Chulho Kim19, Hae-Bong Jeong20, Kwang-Yeol Park20, Chi Kyung Kim21, Jihoon Kang22, Jun Yup Kim22, Hee-Joon Bae22,23, Longting Lin24, Mark Parsons24, Beom Joon Kim22
1Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Republic of Korea (H.-J.H.).
2Artificial Intelligence Research Center, JLK, Inc, Seoul, Republic of Korea (H.-J.H., W.-S.R., Myungjae Lee).
3Department of Radiology (L.S.), Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
4Department of Neurology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea (K.K.).
5Department of Neurology, School of Medicine, Daejeon Eulji Medical Center, Eulji University, Republic of Korea (J.G.K., S.J.L.).
6Department of Neurology, Dong-A University Hospital, Busan, Republic of Korea (J.-K.C.).
7Department of Neurology, Seoul Medical Center, Republic of Korea (T.H.P.).
8Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Republic of Korea (J.-Y.L., K.L.).
9Department of Neurology, Yeungnam University Medical Center, Daegu, Republic of Korea (D.H.K., J.L.).
10Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea (H.-K.P., K.-S.H.).
11Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (Minwoo Lee, M.S.O., K.-H.Y.).
12Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea (D.-S.G., D.-E.K.).
13Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea (H.K., J.-T.K.).
14Department of Neurology, Jeju National University Hospital, Republic of Korea (J.-G.K., J.C.C.).
15Department of Neurology (W.-J.K., J.H.K.), Ulsan University Hospital, University of Ulsan College of Medicine, Republic of Korea.
16Department of Radiology (Y.C.W.), Ulsan University Hospital, University of Ulsan College of Medicine, Republic of Korea.
17Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea (K.S.Y., D.-I.S.).
18Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea (J.-H.H., S.-I.S.).
19Department of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Republic of Korea (S.-H.L., C.K.).
20Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea (H.B.J., K.-Y.P.).
21Department of Neurology, Korea University Guro Hospital, Seoul (C.K.K.).
22Department of Neurology (J.K., J.Y.K., H.-J.B., B.J.K.), Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
23Department of Neurology, College of Medicine, Seoul National University, Republic of Korea (H.-J.B.).
24Department of Neurology, University of New South Wales South Western Sydney Clinical School, Liverpool, Australia (L.L., M.P.).
PubMed DOI

Abstract

BACKGROUND: Hemorrhagic transformation (HT) after recanalization therapy remains a critical concern in acute ischemic stroke management. While severe hemorrhages clearly worsen outcomes, the prognostic impact of mild HT and its optimal prediction methods remain uncertain. In this study, we aimed to evaluate the clinical significance of all HT subtypes and develop automated HT prediction models bas…

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