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Nat Commun2026;17(1)March 7, 2026Journal Article

DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma.

Daniel J Renouf1,2, James T Topham3, Jonathan M Loree4, David F Schaeffer5,6, Jennifer J Knox7,8, Petr Kavan9, Derek Jonker10, Stephen Welch11, Felix Couture12, Frederic Lemay13, Mustapha Tehfe14, Mohammed Harb15, Nathalie Aucoin16, Yoo-Joung Ko17, Patricia A Tang18, Ravi Ramjeesingh19, Brandon M Meyers20, Christina A Kim21, Pan Du22, Shidong Jia22, Joanna M Karasinska3, Sharlene Gill4, Dongsheng Tu23, Chris J O'Callaghan23
1Pancreas Centre BC, Vancouver, BC, Canada. drenouf@bccancer.bc.ca.
2Division of Medical Oncology, BC Cancer, Vancouver, BC, Canada. drenouf@bccancer.bc.ca.
3Pancreas Centre BC, Vancouver, BC, Canada.
4Division of Medical Oncology, BC Cancer, Vancouver, BC, Canada.
5Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
6Division of Anatomic Pathology, Vancouver General Hospital, Vancouver, BC, Canada.
7Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, Toronto, Canada.
8Ontario Institute for Cancer Research, Toronto, ON, Canada.
9Departments of Oncology and Medical Oncology, Sir Mortimer B. Davis Jewish General Hospital, Segal Cancer Centre, McGill University, Montreal, QC, Canada.
10The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
11London Regional Cancer Program, London, ON, Canada.
12CHU de Quebec Research Centre and Faculty of Medicine, Laval University, Quebec City, QC, Canada.
13Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada.
14Hematology and Medical Oncology Service, Centre Hospitalier Universitaire de Montreal, University of Montreal, Montreal, QC, Canada.
15The Moncton City Hospital, Moncton, NB, Canada.
16Hopital Cite-de-la-Sante, Laval, QC, Canada.
17Department of Medicine, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
18Arthur J.E. Child Comprehensive Cancer Centre and University of Calgary, Calgary, AB, Canada.
19Division of Medical Oncology, QEII Health Sciences Centre, Halifax, NS, Canada.
20Juravinski Cancer Centre, Hamilton, ON, Canada.
21CancerCare Manitoba, Winnipeg, MN, Canada.
22Predicine Inc., Hayward, California, USA.
23Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada.
PubMed PMC DOI PDF

Abstract

The CCTG PA.7 study was a randomized phase II trial comparing chemotherapy with and without dual immune checkpoint inhibition in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). In follow-up to the published primary results of the trial, the analysis herein focused on long-term survival and exploratory analysis.Plasma sequencing analysis identified concurrent mutations in DNA dam…

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