Peer-Reviewed Publication
BMC Med Imaging2026;26(1)March 4, 2026Journal Article
Periductal iron-corrected T1 is a predictor of adverse outcomes in large-duct primary sclerosing cholangitis.
Emmanuel A Selvaraj1,2,3,4, Ahmed Ba-Ssalamah5, Sarah Poetter-Lang5, Bruno Paun6, Gerard R Ridgway7, Cayden Beyer6, Anneli Andersson8, Sir Michael Brady6,9, Michele Pansini6,10, Emma L Culver2,3, Adam Bailey2,3, Michael Pavlides DPhil1,2,3
1Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
2Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
3NIHR Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
4South Warwickshire University Hospital Foundation Trust, Warwick, UK.
5Department of Biomedical Imaging and Image- guided Therapy, Medical University of Vienna, General Hospital of Vienna (AKH), Vienna, Austria.
6Perspectum Ltd., Oxford, UK.
7Oxford Brain Diagnostics Ltd., Oxford, UK.
8Perspectum Ltd., Oxford, UK. anneli.andersson@perspectum.com.
9Medical Sciences Division, Department of Oncology, University of Oxford, Oxford, UK.
10Department of Radiology, Clinica Di Radiologia EOC, Istituto Di Imaging Della Svizzera Italiana, Lugano, Switzerland.
Abstract
BACKGROUND: Concentric periductal fibrosis, commonly referred to as “onion skin” fibrosis, is a histological hallmark of primary sclerosing cholangitis (PSC) and associated with the development of biliary-type cirrhosis and end-stage liver disease. Our aim was to investigate whether non-contrast enhanced quantitative MRI can provide a noninvasive biomarker of periductal fibro-inflammation in large…
Create a free account to keep reading
Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.
Want unlimited research access? See Pro plans