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Peer-Reviewed Publication
Nat Hum Behav2026;10(5):906-922.May 1, 2026Journal Article

A crowdsourced megastudy of 12 digital single-session interventions for depression in US adults.

Benjamin T Kaveladze1, Jan G Voelkel2, Michael N Stagnaro3, Mingjing Huang4, Amanda E Smock4, Erin K Sullivan5, Yao M Xu6, Madison P McCall7, Juan Pablo Zapata4, Syed Ishtiaque Ahmed8, Ananya Bhattacharjee8, Iva Georgieva9, Rosa Hernandez-Ramos10, Kenneth S Huber11, Julia K Jennings12, Arianna C Kirk13, Robert S M Knowles14, Rachel Kornfield4, Monika Neff Lind10, Michelle Liu15, Michael A Liut16, Alex T Mariakakis8, Ali M Mattu17, Adam P McGuire18, Jonah Meyerhoff4, Alissa J Mrazek12, Michael D Mrazek12, David C Mohr4, Robert R Morris14, Christopher J Mosunic11, Hana Nip10, Allen Olson-Urtecho19, Jessa R Podell12, Dustyn S Ransom12, Shireen L Rizvi20, Matthew W Southward21, Sarah Elizabeth Stoeckl10, Madison E Taylor10, Amy R Texter22, Calvin V Tower12, Angelique N Trotter12, Joseph J Williams8, Katherine E Wislocki10, Elijah J Woodson12, John Protzko5, Lorenzo Lorenzo-Luaces23, Stephen M Schueller10, Matthew K Nock24, Jessica L Schleider4
1Northwestern University, Chicago, IL, USA. bkavelad@uci.edu.
2Cornell University, Ithaca, NY, USA.
3Yale University, New Haven, CT, USA.
4Northwestern University, Chicago, IL, USA.
5Central Connecticut State University, New Britain, CT, USA.
6Stanford University, Palo Alto, CA, USA.
7University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
8University of Toronto, Toronto, Ontario, Canada.
9Institute of Philosophy and Sociology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
10University of California, Irvine, Irvine, CA, USA.
11Calm Health, Palo Alto, CA, USA.
12University of Texas at Austin, Austin, TX, USA.
13Visionari Media, Santa Barbara, CA, USA.
14Koko, San Francisco, CA, USA.
15Loyola University Chicago, Chicago, IL, USA.
16University of Toronto Mississauga, Mississauga, Ontario, Canada.
17Mind Stuff LLC, Oakland, CA, USA.
18University of Texas at Tyler, Tyler, TX, USA.
19Studio Bahia, Houston, TX, USA.
20Albert Einstein College of Medicine, New York, NY, USA.
21The Ohio State University, Columbus, OH, USA.
22University of Colorado Boulder, Boulder, CO, USA.
23Indiana University Bloomington, Bloomington, IN, USA.
24Harvard University, Cambridge, MA, USA.
PubMed DOI

Abstract

Digital, self-guided, single-session interventions (SSIs) deliver structured psychological support within one interaction. Here we crowdsourced 66 diverse 10-min SSIs for depression and, with input from researchers and lived-experience experts, selected 11 for testing in a preregistered online randomized controlled trial (ClinicalTrials.gov ID: NCT06856668 ). US adults (N = 7,505) experiencing ele…

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