Health AI Central
Share:
Peer-Reviewed Publication
Biotechniques2026;78(1-12):41-54.January 1, 2026Journal Article

3in1: an ultra-fast phage display biopanning method overcoming the biopanning bias and yielding more diverse binders.

Samson Lichtenstein1, Morgane Valles1, Michael Mullin1, Aleardo Morelli1
1LabGenius Therapeutics (LabGenius Ltd), London, UK.
PubMed DOI

Abstract

Phage display combined with biopanning is a powerful method for the discovery of therapeutic antibodies. Classic biopanning is lengthy and labor-intensive, requiring at least five days of work. The biopanning process is plagued by a bias toward binders with propagation advantages, causing a loss in diversity. We present a more efficient biopanning technique named 3in1 biopanning. Using non-denatur…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.