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Peer-Reviewed Publication
Drug Metab Pharmacokinet2026;67101526.April 1, 2026Journal Article

UDP-Glucuronosyl transferase mediated drug-drug interactions: An Industry perspective on recommended in vitro studies.

David M Stresser1, Michael A Zientek2
1Quantitative & Translational ADME Sciences, AbbVie, 1 N. Waukegan Rd., N. Chicago, IL, 60064, USA. Electronic address: David.Stresser@abbvie.com.
2Treeline Biosciences, 3985 Sorrento Valley Blvd, Suite 110, San Diego, CA, 92121, USA.
PubMed DOI

Abstract

Uridine 5'-diphospho-glucuronosyltransferases (UGT) are the best known and most well characterized sugar conjugation biotransformation enzymes. Their main function is to catalyze conjugation of glucuronic acid (sugar) to an exposed (or created) hydroxyl, amine or other nucleophilic functional group on a substrate, known as an aglycone. Since these enzymes are subject to inhibition and induction, t…

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