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Peer-Reviewed Publication
BMC Med Res Methodol2026;26(1)February 26, 2026Journal Article

Subgroup analysis methods for time-to-event outcomes in heterogeneous randomized controlled trials.

Valentine Perrin1, Nathan Noiry2, Nicolas Loiseau2, Alex Nowak2
1Owkin Inc., New York, USA. valentine.perrin@owkin.com.
2Owkin Inc., New York, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Non-significant randomized controlled trials can hide subgroups of good responders to experimental drugs, thus hindering subsequent development. Identifying such heterogeneous treatment effects is key for precision medicine and many post-hoc analysis methods have been developed for that purpose. While several benchmarks have been carried out to identify the strengths and weaknesses of…

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