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Peer-Reviewed Publication
J Control Release2026;393114748.May 10, 2026Journal Article

Ultrasound cavitation therapy: inducing tumor drug delivery and blood flow changes with clinical ultrasound tools.

Connor Krolak1, Lance De Koninck1, Sherry Gu1, Yak-Nam Wang2, Jeffry E Powers3, Michalakis Averkiou4
1Department of Bioengineering, University of Washington, Seattle, WA, USA.
2Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, USA.
3Philips Ultrasound, Bothell, WA, USA.
4Department of Bioengineering, University of Washington, Seattle, WA, USA. Electronic address: maverk@uw.edu.
PubMed PMC DOI PDF

Abstract

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer-related deaths, remains difficult to treat due to underlying liver disease, abnormal tumor vasculature, elevated interstitial fluid pressure (IFP), and immune suppression. We developed a theranostic approach using ultrasound cavitation with a clinical scanner and FDA-approved microbubbles to enhance vascular permeability and drug d…

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