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Am J Respir Crit Care Med2026;212(6):1343-1346.June 1, 2026Journal Article

The CFTR potentiator icenticaftor for treatment of bronchiectasis: an international phase 2, double-blind, randomized placebo-controlled trial.

Wei-Jie Guan1,2, Charles S Haworth3, Harm A W M Tiddens4,5,6, Michael R Loebinger7,8, Adam T Hill9, Oriol Sibila10,11,12, Felix C Ringshausen13,14,15, Bridget D Stuart16, Yingying Wang17, J Stuart Elborn18, Nan-Shan Zhong1,2, James D Chalmers19,20
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.
2China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University, Guangzhou, P. R. China.
3Royal Papworth Hospital NHS Foundation Trust and Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
4Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
5Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
6Thirona, Nijmegen, The Netherlands.
7Host Defence Unit, Royal Brompton Hospital, London, United Kingdom.
8NHLI, Imperial College London, London, United Kingdom.
9Centre for Inflammation Research Institute for Regeneration and Repair, The University of Edinburgh Edinburgh BioQuarter, Edinburgh, United Kingdom.
10Centro de Investigación Biomédica en Red de Enfermedades Respiratorias M.P. (CIBERES), Barcelona, Spain.
11Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
12Respiratory Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.
13Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.
14German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany.
15European Reference Network on Rare and Complex Respiratory Diseases (ERN-LUNG), Frankfurt, Germany.
16Biomedical Research, Novartis, Cambridge, MA, United States.
17Analytics-EDA, Novartis, Shanghai, China.
18Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom.
19Division of Respiratory Medicine and Gastroenterology, University of Dundee, Dundee, United Kingdom.
20John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
PubMed DOI

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