Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults.

M Kyla Shea¹, Joshua L Rutt², Bess Dawson-Hughes², Puja Agarwal³, Xueyan Fu², Sarah L Booth²

¹USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States. Electronic address: kyla.shea@tufts.edu.

²USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.

³Department of Internal Medicine, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Circulating biomarkers are often used to infer nutrient intakes and overall nutrient status, but may not accurately reflect nutrient concentrations in specific tissues. Since direct measurement of human tissue nutrient concentrations is rarely feasible, researchers rely on biomarkers as proxies. Studies linking diet, circulating biomarkers, and tissue nutrient concentrations are needed…

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Mentioned Companies

Kyla
affiliation

NIH Funding

Grant #11181636
Dietary factors, neuroinflammation, plasma neurodegenerative biomarkers and Alzheimer’s disease in diverse cohorts
RUSH UNIVERSITY MEDICAL CENTER
$755,455 (FY2025)

Other Funding

NIA NIH HHS(R01 AG017917)
United States
NIA NIH HHS(R01 AG051641)
United States
NIA NIH HHS(R01 AG085483)
United States

MeSH Terms

Humans0Biomarkers0Female0Male0Aged0Brain*Diet*Vitamin K 20Vitamin K 10Aged, 80 and over0Vitamin K*Vitamin D*Calcium-Binding Proteins0Extracellular Matrix Proteins0Calcifediol*Matrix Gla Protein0Nutritional Status0

Keywords

biomarkersbraindietary intakesolder adultsvitamin Dvitamin K

Article Info

PMID: 41722817
PMCID: PMC13034641
DOI: 10.1016/j.tjnut.2026.101428
Received: January 7, 2026
Accepted: February 14, 2026

How to Cite

Shea MK et al. Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults. J Nutr2026;156(4):101428. doi:10.1016/j.tjnut.2026.101428

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