Peer-Reviewed Publication
J Affect Disord2026;403121444.June 15, 2026Journal Article

Implementing artificial intelligence (AI) to facilitate health outcomes in mood disorders: Application versus aspiration.

Roger S McIntyre1, Charles B Nemeroff2, Natalie Rasgon3
1Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, ON, Canada. Electronic address: roger.mcintyre@bcdf.org.
2Department of Psychiatry and Behavioral Sciences, University of Texas at Austin, Dell Medical School, Austin, TX, United States of America. Electronic address: cnemeroff@austin.utexas.edu.
3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, United States of America; Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, United States of America. Electronic address: nrasgon@stanford.edu.

Abstract

The burden of depressive and bipolar disorders at the individual and societal level are extraordinary and increasing. For decades, evidence-based treatments for these conditions have been established but outcomes amongst individuals with lived experience remains suboptimal. Notwithstanding calls to close gaps between current practice and best practice, there is an absence of evidence that overall…

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