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Sci Rep2026;16(1)February 10, 2026Journal Article

Analytical and clinical validation of CancerMaster, an automated targeted NGS panel, for tumor-only precision oncology.

Jingmin Che1, Woo Sun Kwon1, Jaeyoung Kim2, Erkhembayar Jadamba3, Hyo Jun Han4, Yuhnam Kim4, Choong-Kun Lee1,5, Chan Hee Park1, Ye Jin Moon1,6, Han Byeol Mun1,6, Hyun Cheol Chung1,5, Sun Young Rha7,8,9
1Song-dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
2Pharos iBio Co., Ltd, Seoul, Republic of Korea.
3Mogam Institute for Biomedical Research, Seoul, Republic of Korea.
4Celemics, Seoul, Republic of Korea.
5Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
6Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
7Song-dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea. rha7655@yuhs.ac.
8Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. rha7655@yuhs.ac.
9Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea. rha7655@yuhs.ac.
PubMed PMC DOI PDF

Abstract

We developed a CancerMaster-targeted next generation sequencing (NGS) panel covering 524 key genes specifically designed for the multidimensional molecular profiling of solid tumors. We aimed to establish CancerMaster as an asynchronous and parallel one-stop automated analysis pipeline with a reporting system to overcome the delay in existing NGS approaches. This panel can detect common genomic al…

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