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Clin Cancer Res2026;32(9):1755-1765.May 1, 2026Journal Article

Urinary Biomarkers Objectively Measure Minimal Residual Disease in Non-Muscle-Invasive Bladder Cancer.

Andrew B Katims1,2, Charlie White3, Syed Muneeb Alam1,4, Mark Farha1,5, Sadra Sepehri6, Manuel De Jesus Escano1,7, Neeta D'Souza1,8, Gamze Gokturk Ozcan9, Merve Basar9, Anthony Martinez Benitez1, Melissa McCarter1, Morgan Tomberlin1, David B Solit10, Gopa Iyer10, Pan Du11, Shidong Jia11, Alvin C Goh1, Timothy F Donahue1, Judy Sarungbam9, Bernard H Bochner1, Max Kates6, Irina Ostrovnaya3, Hikmat Al-Ahmadie9, Oscar Lin9, Eugene J Pietzak1
1Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
2Department of Urology, Westchester Medical Center, New York Medical College, Valhalla, New York.
3Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
4Department of Urology, Yale University, New Haven, Connecticut.
5Department of Urology, Weill Cornell Medicine, New York, New York.
6Brady Urologic Institute, Johns Hopkins Medicine, Baltimore, Maryland.
7Urology Institute, DHR Health, Edinburg, Texas.
8Department of Anesthesia, SUNY Downstate Medical Center, Brooklyn, New York.
9Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
10Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
11Predicine, Inc., Hayward, California.
PubMed PMC DOI PDF

Abstract

PURPOSE: To determine whether carcinoma in situ (CIS) is a sufficient measure of minimal residual disease (MRD) in non-muscle-invasive bladder cancer (NMIBC) and evaluate alternative measures of MRD. EXPERIMENTAL DESIGN: We evaluated the concordance of CIS on transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) to determine eradication rates of clinical CIS (cCIS) by TURBT…

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