Peer-Reviewed Publication
Front Immunol2025;161719808.January 1, 2025Journal Article
Synergy between immune system and antibiotics drives infection control in mice.
Rajalekshmy G Padmakumari1, Ruchi Roy2, Foyez Mahmud3, Deepa Dehari1, Getnet Tesfaw1, Christi Thomas1, Athena M Soulika1,4, Roslyn Rivkah Isseroff1,5, Sasha H Shafikhani1,6,7,8
1Department of Dermatology, University of California Davis, Sacramento, CA, United States.
2UICentre for Drug Discovery, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, United States.
3VeriSim Life Inc., San Francisco, CA, United States.
4Department of Dermatology, Shriners Hospital for Children, Sacramento, CA, United States.
5Dermatology Section, VA Northern California Health Care System, Mather, CA, United States.
6Microbiology Graduate Group (MGG), University of California Davis, Sacramento, CA, United States.
7Graduate Group in Immunology (GGI), University of California Davis, Sacramento, CA, United States.
8Cancer Center, University of California Davis, Sacramento, CA, United States.
Abstract
BACKGROUND: Antibiotics and host immunity are traditionally viewed as independent defenses, with antibiotics reducing bacterial load to levels manageable by the immune system. Modeling studies, however, predict that synergy between these defenses is critical for infection control, but this has not been experimentally verified.
METHODS: We tested this concept using a Pseudomonas aeruginosa wound i…
Create a free account to keep reading
Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.
Want unlimited research access? See Pro plans