Diffusion Tensor MRI and Spherical-Deconvolution-Based Tractography on an Ultra-Low Field Portable MRI System.

James Gholam¹, Phil Schmid¹, Joshua Ametepe¹, Alix Plumley¹, Leandro Beltrachini², Francesco Padormo³, Rui Teixeira³, Rafael O'Halloran³, Kaloian Petkov⁴, Klaus Engel⁵, Steven C R Williams⁶, Sean Deoni⁷, Mara Cercignani¹, Derek K Jones¹

¹Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Cardiff, UK.

²School of Physics and Astronomy, Cardiff University, Cardiff, Wales, UK.

³Hyperfine, Inc., Guilford, Connecticut, USA.

⁴Siemens Medical Solutions, Malvern, Pennsylvania, USA.

⁵Siemens Healthineers AG, Erlangen, Germany.

⁶Centre for Neuroimaging Sciences, King's College London, London, Camberwell, UK.

⁷Maternal, Newborn & Child Health (MNCH) and Discovery & Translational Sciences (D&T), Bill & Melinda Gates Foundation, Seattle, Washington, USA.

PubMed PMC DOI PDF

Abstract

Ultra-low-field (ULF) MRI is emerging as an alternative modality to high field (HF) MRI due to its lower cost, minimal siting requirements, portability and enhanced accessibility-factors that enable large-scale deployment. Although ULF-MRI exhibits a lower signal-to-noise ratio (SNR), advanced imaging and data-driven denoising methods enabled by high-performance computing have made contrasts like…

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