Exploration of Semiconductor Chip-Based Single-Molecule Protein Sequencing for Identification of Hemoglobin Variants.

Ruben Y Luo^1,2, Mathivanan Chinnaraj³, Kristin Blacklock³, Douglas Pike³, Ilya Chorny³, John Vieceli³, Carolyn V Wong²

¹Department of Pathology, School of Medicine, Stanford University, Stanford, California 94304, United States.

²Clinical Laboratories, Stanford Health Care, Palo Alto, California 94304, United States.

³Quantum-Si Inc., Branford, Connecticut 06405, United States.

PubMed DOI

Abstract

Identification of hemoglobin (Hb) variants is of significant value in the clinical diagnosis of hemoglobinopathies. Conventional methods used to identify Hb variants in clinical laboratories can narrow down the range of candidates for a Hb variant sample but are unable to pinpoint the exact Hb variant. In this study, Next-Generation Protein Sequencing (NGPS), a semiconductor chip-based single-mole…

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