Despite simplified diagnostic criteria, intraobserver and interobserver variability remain in the interpretation of colorectal serrated polyps.

Adam L Booth¹, Emina E Torlakovic², Runjan Chetty³, Alton Brad Farris⁴, Emma E Furth⁵, John R Goldblum⁶, Teri A Longacre⁷, Mari Mino-Kenudson⁸, Robert H Riddell⁹, Christophe Rosty^10,11,12, Amitabh Srivastava¹³, Rhonda K Yantiss¹⁴, Brian Cox¹⁵, Raul S Gonzalez⁴

¹Washington University School of Medicine, St. Louis, Missouri, USA.

²University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

³Deciphex/Diagnexia, Dublin, Ireland.

⁴Emory University, Atlanta, Georgia, USA.

⁵University of Pennsylvania, Philadelphia, Pennsylvania, USA.

⁶Cleveland Clinic, Cleveland, Ohio, USA.

⁷Stanford University, Palo Alto, California, USA.

⁸Massachusetts General Hospital, Boston, Massachusetts, USA.

⁹University of Toronto, Toronto, Ontario, Canada.

¹⁰Envoi Specialist Pathologists, Kelvin Grove, Queensland, Australia.

¹¹Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

¹²Colorectal Oncogenomic Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.

¹³Memorial Sloan Kettering Cancer Center, New York, New York, USA.

¹⁴University of Miami, Miami, Florida, USA.

¹⁵Pacific Rim Pathology, San Diego, California, USA.

PubMed DOI

Abstract

AIMS: Many studies have highlighted interobserver variability in histologic distinction between colorectal sessile serrated lesion (SSL) and hyperplastic polyp (HP). In 2019, the WHO updated their criteria for the diagnosis of SSL, requiring 'at least 1 unequivocal architecturally distorted serrated crypt'. Even with this simplified criterion, as well as experience accumulated in recognizing SSL o…

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