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Peer-Reviewed Publication
Am J Psychiatry2026;183(2):98-107.February 1, 2026Journal Article

Brain Neuroplasticity Mechanisms in Psychiatric Illnesses and in the Development of Novel Treatments.

Patricio O'Donnell1, Amit Etkin1,2, Husseini Manji3,4
1Alto Neuroscience, Mountain View, CA.
2Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA.
3Department of Psychiatry, Oxford University, Oxford, UK.
4Department of Psychiatry, Yale University, New Haven, CT.
PubMed DOI

Abstract

Neuroplasticity-the brain's capacity to modify synaptic strength and connectivity-likely underlies both the pathophysiology of psychiatric disorders and the mechanisms through which treatments exert therapeutic effects. Direct assessment of plasticity requires measuring changes in synaptic responses, which remains technically challenging in humans. The most proximal human indicators are behavioral…

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