Peer-Reviewed Publication
Nat Hum Behav2026;10(4):777-802.April 1, 2026Journal Article
Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.
Andrea I Luppi1,2,3,4, Lynn Uhrig5,6, Jordy Tasserie5,7, Pedro A M Mediano8, Fernando E Rosas9,10,11, S Parker Singleton12, Daniel Gutierrez-Barragan13, Silvia Gini13,14, Pablo Castro5, Camilo M Signorelli5,15,16,17, Daniel Golkowski18, Andreas Ranft19, Rüdiger Ilg18,20, Denis Jordan19, Kanako Muta21,22, Junichi Hata21,22, Hideyuki Okano22,23, Zhen-Qi Liu24, Yohan Yee24,25, Alain Destexhe26, Rodrigo Cofre26,27, David K Menon28, Alessandro Gozzi12, Bechir Jarraya5,26,29, Emmanuel A Stamatakis28
1Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. andrea.luppi@psych.ox.ac.uk.
2St John's College, Cambridge, UK. andrea.luppi@psych.ox.ac.uk.
3Centre for Eudaimonia and Human Flourishing, Department of Psychiatry, University of Oxford, Oxford, UK. andrea.luppi@psych.ox.ac.uk.
4McGill University, Montreal, Quebec, Canada. andrea.luppi@psych.ox.ac.uk.
5Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France.
6Department of Anesthesiology and Critical Care, Necker Hospital, AP-HP, Université de Paris Cité, Paris, France.
7Center for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
8Department of Computing, Imperial College London, London, UK.
9Centre for Eudaimonia and Human Flourishing, Department of Psychiatry, University of Oxford, Oxford, UK.
10Informatics Department, University of Sussex, Brighton, UK.
11Centre for Complexity Science, Imperial College London, London, UK.
12Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
13Centre for Neuroscience and Cognitive Systems, Italian Institute of Technology, Rovereto, Italy.
14Center for Mind and Brain Sciences, University of Trento, Rovereto, Italy.
15Department of Computer Science, University of Oxford, Oxford, UK.
16Center for Philosophy of Artificial Intelligence, University of Copenhagen, Copenhagen, Denmark.
17Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, Brussels, Belgium.
18Department of Neurology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
19Department of Anesthesiology and Intensive Care, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
20Department of Neurology, Asklepios Clinic, Bad Tolz, Germany.
21Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa, Tokyo, Japan.
22Laboratory for Marmoset Models of Brain Diseases, RIKEN Center for Brain Science, Wako, Saitama, Japan.
23Regenerative Medicine Research Center, Keio University, Kanagawa, Japan.
24McGill University, Montreal, Quebec, Canada.
25Department of Radiology, University of Calgary, Calgary, Canada.
26Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France.
27INRIA Centre, Universite Cote d'Azur, Nice, France.
28Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
29Department of Neurology, Hopital Foch, Suresnes, France.
Abstract
The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system dis…
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