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Metabolites2026;16(1)January 4, 2026Journal Article

Development and Validation of a Targeted Metabolomic Tool for Metabotype Classification in Schoolchildren.

Sheyla Karina Hernández-Ramírez1,2, Diego Arturo Velázquez-Trejo2,3, Eduardo Sandoval-Colín2, Cristóbal Fresno4, Mariana Flores-Torres2, Ernestina Polo-Oteyza5, María José Garcés-Hernández2, Nayely Garibay-Nieto6,7, Isabel Ibarra-González8, Marcela Vela-Amieva9, Guadalupe Estrada-Gutierrez10, Felipe Vadillo-Ortega2
1Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
2Unidad de Vinculación de la Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
3Programa de Maestría y Doctorado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
4Red de Apoyo a la Investigación, Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
5Fundación Mexicana para la Salud, Mexico City 14610, Mexico.
6Unidad de Bienestar Infantil, Hospital General de México Dr. Eduardo Liceaga, Mexico City 06720, Mexico.
7Healthec By Tec Salud, Mexico City 10200, Mexico.
8Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas UNAM, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
9Laboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
10Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
PubMed PMC DOI PDF

Abstract

Background: Metabolomic profiling can uncover metabolic differences among seemingly healthy children, providing opportunities for personalized medicine and early detection of risk biomarkers for future metabolic disorders. This study aimed to identify and internally validate metabotypes in apparently healthy schoolchildren using targeted serum metabolomics and to assess the external validity of th…

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