Derivation of an intrinsic brain activity biomarker for the earliest prediction of cognitive decline.

Leslie S Prichep¹, Syed N Zaidi², Kara Brink², Saloni Kanakia², Bo Liang², Yang Jiang^3,4, Ruben Armañanzas^5,6

¹BrainScope Company, Rockville, MD, 20855, USA. leslie.prichep@brainscope.com.

²BrainScope Company, Rockville, MD, 20855, USA.

³Aging Brain and Cognition Laboratory, Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, USA.

⁴Sanders Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY, USA.

⁵Institute of Data Science and Artificial Intelligence (DATAI), Universidad de Navarra, Pamplona, Spain.

⁶TECNUN School of Engineering, Universidad de Navarra, San Sebastian, Spain.

PubMed PMC DOI PDF

Abstract

Early identification of cognitive decline in the elderly is essential for timely and effective intervention. Current neuroimaging and clinical biomarkers have largely focused on patients with mild cognitive impairment (MCI) and dementias, and though effective, have not been demonstrated to be sensitive to the earliest signs of functional abnormalities. The electroencephalogram (EEG), with a millis…

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