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Peer-Reviewed Publication
Ophthalmol Sci2026;6(2):100907.February 1, 2026Journal Article

Longitudinal Validation of the Artificial Intelligence Algorithm in Home OCT for Age-Related Macular Degeneration-Report 3.

Theodore Leng1, Ella H Leung2, S Krishna Mukkamala2, Mehran R Taban3, Moshe Havilio4, Kester Nahen4, Nishant Mohan4, Gidi Benyamini4, Tiarnan D L Keenan5
1Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, California.
2Georgia Retina, Atlanta, Georgia.
3Macula Retina Vitreous Research Institute, Torrance, California.
4Notal Vision Inc., Manassas, Virginia.
5Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Abstract

PURPOSE: Longitudinal validation of the artificial intelligence-based Notal OCT Analyzer (NOA) for identification of clinically significant changes in the trajectories of retinal total hypo-reflective volume (TRO) from daily home OCT (HOCT) self-imaging in eyes with age-related macular degeneration. DESIGN: Post hoc analysis of the HOCT Fluid Visualization Agreement Study. PARTICIPANTS: Three hu…

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