Peer-Reviewed Publication
J Clin Gastroenterol2026January 19, 2026Journal Article
Clinical Validation of a Simplified, Scrape-Free Collection Method for Multitarget Stool RNA Testing in Colorectal Cancer Screening.
Erica K Barnell1,2, Theodore R Levin3, Samir Gupta4, John M Carethers5, Aasma Shaukat6,7, Kimberly Kruse2, Ryan Ghannam2, David A Lieberman8
1Department of Medicine, Washington University School of Medicine, Saint Louis, MO.
2Geneoscopy Inc., St. Louis, MO.
3Kaiser Permanente Division of Research, Pleasanton, CA.
4Department of Medicine, Division of Gastroenterology and Hepatology, Moores Cancer Center, San Diego, CA.
5Department of Medicine, Division of Gastroenterology and Hepatology, Moores Cancer Center, The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA.
6Division of Gastroenterology, NYU Grossman School of Medicine, New York, NY.
7Department of Medicine, VA New York Harbor Health Care System, New York, NY.
8Department of Medicine, Division of Gastroenterology, Oregon Health and Science University, Portland, OR.
Abstract
BACKGROUND AND AIMS: Most colorectal cancer (CRC) screening tests, including fecal immunochemical (FIT) and multitarget stool DNA tests, require patients to scrape a stool sample at home before mailing it to a central lab. This requirement not only deters screening adherence but can also introduce risks of human error, environmental exposure, and transit-related issues. The multitarget stool RNA t…
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