ColoSense
First FDA-approved RNA-based stool test for colorectal cancer screening
Company profile
Company profile
Geneoscopy is a precision medicine company focused on transforming gastrointestinal health through innovative molecular diagnostic tests. The company has developed a proprietary stool-derived eukaryotic RNA (seRNA) technology platform that enables noninvasive screening, detection, and monitoring of gastrointestinal diseases. Geneoscopy's flagship product, ColoSense, is the first FDA-approved RNA-based stool test for colorectal cancer screening in adults aged 45 and older. The company's mission is to empower patients and healthcare providers with molecular-based tests that help prevent, detect, and monitor disease. By offering a convenient, at-home collection method, Geneoscopy addresses the significant gap in colorectal cancer screening rates, where over 40% of eligible patients fail to get screened due to the inconvenience and invasive nature of colonoscopies. Beyond colorectal cancer, Geneoscopy is advancing applications of its stool RNA technology to monitor disease activity and predict therapeutic response in inflammatory bowel disease. The company partners with biopharma organizations and research institutions to develop companion diagnostics and clinical trial tools. Geneoscopy's platform-agnostic RNA extraction technology can be evaluated using next-generation sequencing, ddPCR, qPCR, molecular barcoding, or microarray technology, providing comprehensive insights into the stool-derived transcriptome for various gastrointestinal disease indications.
Company description Geneoscopy official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Other deployment with recorded integration context.
Company milestones
FDA approval of ColoSense as the first RNA-based stool test for colorectal cancer screening. Dr. Erica Barnell completed MD/PhD in 2023. Expansion into inflammatory bowel disease monitoring applications.
Partnerships
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
First FDA-approved RNA-based stool test for colorectal cancer screening
Second generation multi-target stool RNA test for colorectal cancer screening
Stool RNA assay for monitoring inflammatory bowel disease activity
Proprietary stool-derived eukaryotic RNA extraction and analysis platform
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
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Research
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Jul 1, 2026
Using wastewater for population-level colorectal cancer surveillance: a future research agenda.Journal of epidemiology and community health · Jun 10, 2026
Reply.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Mar 27, 2026
Reply.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Feb 1, 2026
Clinical Validation of a Simplified, Scrape-Free Collection Method for Multitarget Stool RNA Testing in Colorectal Cancer Screening.Journal of clinical gastroenterology · Jan 19, 2026
Analytical validation of a scrape-free multitarget stool RNA test for colorectal cancer screening.Practical laboratory medicine · Dec 1, 2025
Clinical validation
NCT07069556 · Sponsor · RECRUITING
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test StudyNCT04739722 · Sponsor · COMPLETED
Regulatory
No linked records are currently available.
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
Addresses the 40% of eligible patients who fail to get screened for colorectal cancer
Detection of high-risk adenomas and colorectal cancer through at-home stool collection
05 · Leadership
Leadership profiles and professional links from the current Company record.
06 · Company updates
Recent articles published on Geneoscopy's official website.
07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies using AI to analyze genomic, proteomic, metabolomic, or multi-omics data to provide personalized treatment recommendations, identify genetic risks, or develop targeted therapies. Includes genomic sequencing platforms with AI analysis, preventive medicine based on genetic risk assessment, and longevity care based on molecular and genetic data.
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