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Peer-Reviewed Publication
Commun Med (Lond)2026;6(1)January 15, 2026Journal Article

Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT).

Jessica McFadyen1, Johanna Habicht2, Larisa-Maria Dina2,3, Ross Harper2, Tobias U Hauser2,4,5,6, Max Rollwage2
1Limbic Limited, London, UK. drjessicajean@gmail.com.
2Limbic Limited, London, UK.
3Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
4Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
5Department of Psychiatry and Psychotherapy, Medical School and University Hospital, Eberhard Karls University of Tubingen, Tübingen, Germany.
6German Center for Mental Health (DZPG), Tübingen, Germany.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Shortages in mental healthcare lead to long periods of inadequate support for many patients. While digital interventions offer a scalable solution to this unmet clinical need, patient engagement remains a key challenge. Generative artificial intelligence (genAI) presents an opportunity to deliver highly engaging, personalized mental health treatment at scale. METHODS: In a pre-registe…

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