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Peer-Reviewed Publication
Tremor Other Hyperkinet Mov (N Y)2026;161.January 1, 2026Journal Article

Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor.

Stuart H Isaacson1, Elizabeth Peckham2, Winona Tse3, Melita T Petrossian4, Michael J Soileau5, Mark Lew6, Cameron Dietiker7, Nijee Luthra7, Pinky Agarwal8, Rohit Dhall9, John Morgan10, Ejaz A Shamim11,12, Holly A Shill13, Fernando L Pagan14, Pravin Khemani15, Jessica Tate16, Lan Luo17, William Ondo18,19, Mark Hallett20, Chiahao Lu21, Kathryn H Rosenbluth21,22, Scott L Delp23, Rajesh Pahwa24
1Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, USA.
2Central Texas Neurology Consultants, Round Rock, TX, USA.
3Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
4Pacific Neuroscience Institute, Pacific Movement Disorders Center, Santa Monica, CA, USA.
5Texas Movement Disorder Specialists, Georgetown, TX, USA.
6Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.
7Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
8Booth Gardner Parkinson's Center, Evergreen Health, Kirkland, WA, USA.
9Movement Disorders Clinic, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
10Department of Neurology, Augusta University, Augusta, GA, USA.
11Mid-Atlantic Kaiser Permanente Neuroscience Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD, USA.
12Department of Neurology, Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD, USA.
13Barrow Neurological Institute, University of Arizona, Phoenix, AZ, USA.
14Department of Neurology, Georgetown University Hospital, Washington, DC, USA.
15Department of Neurology, Swedish Neuroscience Institute, Seattle, WA, USA.
16Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
17Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
18Department of Neurology, Houston Methodist Neurological Institute, Houston, TX, USA.
19Department of Neurology, Weill Cornell Medical College, New York, NY, USA.
20Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
21Cala Health, San Mateo, CA, USA.
22Stanford University School of Medicine, Palo Alto, CA, USA.
23Department of Bioengineering and Mechanical Engineering, Stanford University, Palo Alto, CA, USA.
24Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

Abstract

BACKGROUND: Transcutaneous afferent patterned stimulation (TAPS) is a non-invasive, wrist-worn neurostimulation therapy that has demonstrated acute and short-term lasting tremor reduction in patients with essential tremor (ET). However, the longer-term improvement in underlying tremor severity from consistent use of TAPS has not been fully explored. METHODS: We conducted a retrospective analysis…

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