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Peer-Reviewed Publication
Nat Commun2026;17(1):1359.January 10, 2026Journal Article

Rad51 determines pathway usage in post-replication repair.

Damon Meyer1,2, Steven K Gore1, Jie Liu1, Shannon J Ceballos1,3, Shih-Hsun Hung1,4, Giordano Reginato5,6, Maria I Cano-Linares7, Katarzyna H Maslowska8,9, Florencia Villafañez8,10, Clare Fasching1,11, Christopher Ede1,12, Vincent Pagès8, Felix Prado7, Petr Cejka5, Wolf-Dietrich Heyer13
1Department of Microbiology & Molecular Genetics, University of California, Davis, CA, USA.
2California Northstate University, College of Health Sciences, Rancho Cordova, CA, USA.
3Turtle Tree, Woodland, CA, USA.
4Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan, ROC.
5Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
6Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA.
7Centro Andaluz de Biología Molecular y Medicina Regenerativa -CABIMER; Consejo Superior de Investigaciones Científicas; Universidad de Sevilla; Universidad Pablo de Olavide, Seville, Spain.
8Cancer Research Center of Marseille: Team DNA Damage and Genome Instability, CNRS, Aix Marseille Univ, Inserm, Institut Paoli-Calmettes, Marseille, France.
9Institute of Molecular Biology (IMB), Mainz, Germany.
10OncoPrecision, Córdoba, Argentina.
11Melio Labs, Santa Clara, CA, USA.
12Fulgent Genetics, Temple City, CA, USA.
13Department of Microbiology & Molecular Genetics, University of California, Davis, CA, USA. wdheyer@ucdavis.edu.
PubMed PMC DOI PDF

Abstract

Stalled replication forks are processed in post-replication repair by homologous recombination, fork regression, and translesion DNA synthesis. However, the regulation of pathway usage is not fully understood. Rad51 protein maintains genomic stability through its roles in recombination and in protecting stalled replication forks. We report isolation of mutations in Saccharomyces cerevisiae Rad51 t…

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