The role of gut microbiota in chronic intestinal pseudo-obstruction: exploring fecal microbiota transplantation as a treatment option.

Giada De Palma¹, Anna Costanzini², Vidhyalakshmi Mohan¹, Sacha Sidani¹, Zarwa Saqib¹, Marc Pigrau¹, Jun Lu¹, Natalia Causada Calo¹, Ines Pinto-Sanchez¹, Elena F Verdu¹, Margaret Marcon³, Giovanni Barbara⁴, Vincenzo Stanghellini⁴, Roberto De Giorgio², Stephen M Collins¹, Premysl Bercik¹

¹Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Canada.

²Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

³Division of Gastroenterology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

⁴IRCCS University Hospital, Bologna, Italy; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy.

PubMed PMC DOI PDF

Abstract

Chronic intestinal pseudo-obstruction (CIPO) is characterized by bowel dilation and obstructive symptoms without any structural blockage. Although the microbiota is known to affect gastrointestinal function, its role in CIPO is poorly understood. We aimed to characterize the CIPO microbiota, investigate its role in disease expression and explore the therapeutic role of fecal microbiota transplanta…

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