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Peer-Reviewed Publication
Drug Saf2026;49(5):541-552.May 1, 2026Journal Article

Standardizing and Comparing Management Recommendations for Potential Drug-Drug Interactions Across Different Interaction Checkers.

Lelio Crupi1,2, Louis Letinier3, Vianney Jouhet4, Sébastien Cossin5,6, Antoine Pariente1,7, Clement Mathieu1,7, Guillaume L Martin3, François Konschelle4, Julie Rouanet1,7, Massimo Carollo8, Gianluca Trifirò8, Emanuela Esposito2, Francesco Salvo9,10
1Université de Bordeaux, INSERM, BPH, Team AHeaD, INSERM U1219, 33000, Bordeaux, France.
2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166, Messina, Italy.
3Synapse Médicine, 33000, Bordeaux, France.
4Service d'Information Médicale, Pôle de Santé Publique, CHU de Bordeaux, Team AHeaD, INSERM U1219, 33000, Bordeaux, France.
5Equipe EDS, CHU de Poitiers, 86000, Poitiers, France.
6Scale-Epi, Centre d'Investigation Clinique INSERM 1402, 86000, Poitiers, France.
7Service de Pharmacologie Médicale, Pôle de Santé Publique, CHU de Bordeaux, 33000, Bordeaux, France.
8Department of Diagnostics and Public Health, University of Verona, 37134, Verona, Italy.
9Université de Bordeaux, INSERM, BPH, Team AHeaD, INSERM U1219, 33000, Bordeaux, France. francesco.salvo@u-bordeaux.fr.
10Service de Pharmacologie Médicale, Pôle de Santé Publique, CHU de Bordeaux, 33000, Bordeaux, France. francesco.salvo@u-bordeaux.fr.
PubMed DOI

Abstract

BACKGROUND: Potential drug-drug interactions (pDDIs) are frequent in clinical care, particularly among older patients. Accurate identification and management of pDDIs are essential for patient safety. Prescribers often rely on interaction checkers (ICs) to screen for pDDIs. However, these tools may provide inconsistent recommendations, potentially leading to suboptimal clinical decisions. OBJECTI…

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