Peer-Reviewed Publication
Head Neck Pathol2026;20(1):6.January 5, 2026Journal Article
Barnaculate Carcinoma in Four Patients: Verrucoid Squamous Cell Carcinoma Subtype with TERT and HRAS Oncogenic Variants.
Yu Liang1, Michelle Afkhami1, Lester D R Thompson2, Hanlin Gao3, Ellie G Maghami4, Massimo D'Apuzzo1, Sue Chang1, Diana Bell1,5, Mihan Telatar1, Thomas J Gernon4, Huiqing Wu6
1Department of Pathology, City of Hope National Medical Center, 1500 E. Duarte Rd, Duarte, CA, USA.
2Head and Neck Pathology Consultations, Woodland Hills, CA, USA.
3Fulgent Genetics, El Monte, CA, USA.
4Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
5Department of Pathology and Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
6Department of Pathology, City of Hope National Medical Center, 1500 E. Duarte Rd, Duarte, CA, USA. HWu@coh.org.
Abstract
Well-differentiated squamous cell carcinoma (SCC) in the oral cavity often has limited pleomorphism. Commonly seen in patients with proliferative verrucous leukoplakia, barnaculate carcinoma (BC) is a newly recognized, distinct subtype of well-differentiated SCC which presents with obvious architecture abnormalities but lacks significant pleomorphism. As such, reaching this diagnosis can be extrem…
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