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Peer-Reviewed Publication
Front Endocrinol (Lausanne)2025;161716587.January 1, 2025Comparative Study

Automated basal insulin delivery versus multiple daily injections in type 1 diabetes: results from a randomized parallel controlled trial.

Johan H Jendle1, Satish K Garg2, Charles Thivolet3, Ruth S Weinstock4, Irl B Hirsch5, Mark Evans6, Kurt J Griffin7, Athena Philis-Tsimikas8, Benjamin J Wheeler9, Mark S Kipnes10, Anders L Carlson11, Bruce A Buckingham12, Anuj Bhargava13, Bruce W Bode14, Margaret L Lawson15, Amy B Criego11, Janet B McGill16, John Chip H Reed17, Gnanagurudasan Prakasam18, George Grunberger19, Angela Girelli20, María Asunción Martinez-Brocca21, Mark P Christiansen22, Martin I de Bock23, Yogish C Kudva24, Scott W Lee25, Caroline Yovanovich25, John J Shin25, Toni L Cordero25, Jennifer J F McVean25, Robert A Vigersky25
1School of Medicine, Department of Medical Sciences, Örebro University, Örebro, Sweden.
2Barbara Davis Center for Diabetes, University of Colorado- Denver, Aurora, CO, United States.
3Hybrid Closed-Loop (HCL)- Diab-eCare, Lyon, France.
4Endocrinology, Diabetes and Metabolism, SUNY Upstate Medical University, Syracuse, NY, United States.
5Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, Seattle, WA, United States.
6Institute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
7Sanford Research, Sioux Falls, SD, United States.
8Department of Endocrinology, Diabetes and Metabolism, Scripps Whittier Diabetes Institute, La Jolla, CA, United States.
9Health New Zealand - Southern, Dunedin, New Zealand.
10Diabetes and Glandular Disease Clinic, P.A., San Antonio, TX, United States.
11Park Nicollet International Diabetes Center/Health Partners Institute, Minneapolis, MN, United States.
12Stanford University School of Medicine, Stanford, CA, United States.
13Iowa Diabetes Research, West Des Moines, IA, United States.
14Atlanta Diabetes Associates, Atlanta, GA, United States.
15Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada.
16Division of Endocrinology, Metabolism and Lipid Research, Washington University - Saint Louis, St. Louis, MO, United States.
17Endocrine Research Solutions, Roswell, GA, United States.
18Sutter Children's Center and Sutter Medical Group, Sacramento, CA, United States.
19Grunberger Diabetes and Endocrinology, Bloomfield Hills, MI, United States.
20Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy.
21Department of Endocrinology and Nutrition, Hospital Universitario Virgen Macarena, Sevilla, Spain.
22Flourish Walnut Creek, Walnut Creek, CA, United States.
23Department of Paediatrics and Child Health, New Zealand Clinical Research, University of Otago, Christchurch, New Zealand.
24Department of Endocrinology, Mayo Clinic Rochester, Rochester, MN, United States.
25Medtronic Diabetes, Northridge, CA, United States.
PubMed PMC DOI PDF

Abstract

INTRODUCTION: This study evaluated 6-month effectiveness and safety of automated insulin delivery (AID) in comparison with multiple daily injections (MDI) in pediatric and adult type 1 diabetes (T1D). MATERIALS AND METHODS: Individuals with T1D, aged 2-80 years, were enrolled across 32 international centers (in the United States, Europe, Canada, and New Zealand) and randomized 1:1 to AID interven…

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