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Peer-Reviewed Publication
Cureus2025;17(11):e97666.November 1, 2025Case Reports

New-Onset Systemic Lupus Erythematosus Complicated by Preeclampsia, HELLP Syndrome, and Lupus Nephritis During a Third-Trimester Pregnancy: A Case Report.

Ava Josephson1, Morgan Alexander2, Aditi Radhakrishnan3, Lisbeth Tolentino-Rodriguez4
1College of Pharmacy and Health Sciences, Campbell University, Buies Creek, USA.
2School of Public Health, University of Washington, Seattle, USA.
3Department of Research, Uplift North Hills Preparatory, Irving, USA.
4Department of Research, Global Health Leaders, Gilbert, USA.

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that primarily affects women of reproductive age. Most patients are diagnosed prior to conception; however, new-onset SLE during pregnancy is rare and can mimic common obstetric complications, delaying diagnosis and treatment. Such overlap increases the risk of maternal morbidity and adverse pregnancy outcomes (APOs). A primigravid…

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