Peer-Reviewed Publication
J Gastrointestin Liver Dis2025;34(4):437-450.December 26, 2025Journal Article
Diagnostic Performance of LIVERFASt as a Non-invasive Liver Fibrosis Test: Data from Three Cohorts of Patients with Metabolic Dysfunction-associated Steatotic Liver Disease.
Naim Alkhouri1, Parvez Mantry2, Humberto C Gonzalez3, Rashmee Patil4, Vicki McIntyre5, Anita Kohli6, Madhavi Rudraraju7, Joseph Frank Kosinski8, Bradley S Vander Veen9, Whitfield L Knapple10, Ravi Ravinuthala11, Prasun Kumar Jalal12, Sanjaya K Satapathy13, Bal Raj Bhandari14, Christopher J Christensen15, Victor Ankoma-Sey16, Quynh-An Phan17, Fernando E Membreno18, Gabriel H Lee19, Sudha Kodali20, Abdullah Mubarak21, Hany A Elbeshbeshy22, Robert P Morin23, Reed B Hogan Ii24, Harry E Sarles25, Brigitte Le Bail26, Jean-Baptiste Hiriart27, Juliette Foucher28, Faiza Chermak29, Marie Decraecker30, Pamela Sylvestre31, Matthew M Yeh32, Ronald Quiambao33, Kimberly Mangee34, James Tonascia35, Medhi Sakka36, Rana Alkouri37, Maxime Deregnaucourt38, Dominique Bonnefont-Rousselot39, Stephen A Harrison40, Imtiaz Alam41, Mona Munteanu42, Meena Bansal43, William Alazawi44, Arun J Sanyal45
1Department of Hepatology, Arizona Liver Health, Chandler, Arizona. naim.alkhouri@gmail.com.
2Methodist Health System, Dallas, Texas,. parvezmantry@mhd.com.
3Division of Gastroenterology and Hepatology, Henry Ford Health System, Detroit, Michigan; Wayne State University School of Medicine, Detroit, Michigan, . Hgonzal1@hfhs.org.
4South Texas Research Institute, Edinburg, Texas, . rpatil@pinnacleresearch.com.
5Department of Hepatology, Arizona Liver Health, Tucson, Arizona. vmcintyre@azliver.com.
6Department of Hepatology, Arizona Liver Health, Peoria, Arizona. akohli@azliver.com.
7Pinnacle Clinical Research, San Antonio (S.A.H., M.R.), Texas. mrudraraju@pinnacleresearch.com.
8Premier Medical Group, Clarksville, Tennessee. jkosinski@premiermed.com.
9Premier Medical Group, Clarksville, Tennessee, . bvanderveen@premiermed.com.
10Arkansas Gastroenterology, North Little Rock, Arkansas,. knapplew@yahoo.com.
11Ohio Gastroenterology & Liver Institute (GCGA Physicians LLC), Cincinnati, Ohio. rravinuthala@gastrohealth.com.
12Division of Gastroenterology, Baylor College of Medicine, Houston, Texas. jalal@bcm.edu.
1313. Department of Internal Medicine, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases & Transplantation, Donald and Barbara Zucker School of Medicine for Hofstra/Northwell Health, Manhasset, New York, . ssatapat@northwell.edu.
1414. Delta Research Partners, Bastrop, Louisiana. rbhandari@drbhandari.com.
15Texas Digestive Disease Consultants PLLC d/b/a GI Alliance, Baton Rouge, Louisiana. Cchristensen@tddctx.com.
16Liver Associates of Texas, P.A., Houston, Texas. akobot@aol.com.
17Liver Associates of Texas, P.A., Houston, Texas. qphan@liverassoctx.com.
18DHR Health Institute for Research and Development, Edinburg, Texas. fernandomembreno@yahoo.com.
19Texas Digestive Disease Consultants PLLC d/b/a GI Alliance, Webster, Texas. glee@tddctx.com.
20Sherrie and Alan Conover Center for Liver Disease and Transplantation, J. C. Walter Jr Transplant Center, Houston Methodist Hospital, Houston, Texas. skodali@houstonmethodist.org.
21Liver Center of Texas, Dallas, Texas, . Amubarak@livercenteroftexas.com.
22Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri. hany.elbeshbeshy@health.slu.edu.
23Quality Research, Inc., San Antonio, Texas. bobmorin@qualityresearchinc.com.
24Texas Digestive Disease Consultants PLLC d/b/a GI Alliance, Flowood, Mississippi. reed.hogan@gastrodocs.net.
25Texas Digestive Disease Consultants PLLC d/b/a GI Alliance, Garland, Texas. Harry.Sarles@dhat.com.
26Hepatology Unit, Hôpital Haut Lévêque, Bordeaux University Hospital, Bordeaux. brigitte.lebail@chu-bordeaux.fr.
27Pathology Department, University Hospital of Bordeaux, Bordeaux. jean-baptiste.hiriart@chu-bordeaux.fr.
28Hepatology Unit, Hôpital Haut Lévêque, Bordeaux University Hospital, Bordeaux. juliette.foucher@chu-bordeaux.fr.
29Hepatology Unit, Hôpital Haut Lévêque, Bordeaux University Hospital, Bordeaux. faiza.chermak@chu-bordeaux.fr.
30Hepatology Unit, Hôpital Haut Lévêque, Bordeaux University Hospital, Bordeaux. marie.decraecker@gmail.com.
31Department of Pathology Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. PSylvestre@gastro1.com.
32University of Washington School of Medicine, Department of Laboratory Medicine and Pathology, Seattle, Washington. unaju@icloud.com.
33Medical Affairs, Fibronostics, US Inc., Indian Harbour Beach, Florida. doctorrq65@yahoo.com.
34ObvioHealth, New York, New York. kim.magee@obviohealth.com.
35NIDDK Central Repositories. Bethesda, Maryland, USA. https://doi.org/10.58020/53bk-jk73 . NIDDK-CRsupport@niddk.nih.gov.
36Metabolic Biochemistry Department, Pitié-Salpêtrière Hospital, Public Assistance Paris Hospitals, APHP Sorbonne University, Paris. mehdi.sakka@aphp.fr.
37Metabolic Biochemistry Department, Pitié-Salpêtrière Hospital, Public Assistance Paris Hospitals, APHP Sorbonne University, Paris. rana.alkouri@aphp.fr.
38Metabolic Biochemistry Department, Pitié-Salpêtrière Hospital, Public Assistance Paris Hospitals, APHP Sorbonne University, Paris. maxime.deregnaucourt@aphp.fr.
3932. Metabolic Biochemistry Department, Pitié-Salpêtrière Hospital, Public Assistance Paris Hospitals, APHP Sorbonne University, Paris; 33. Pharmacy Training and Research Unit (UFR), Paris Cité University; CNRS, Inserm, UTCBS, Paris. dominique.rousselot@aphp.fr.
40Pinnacle Clinical Research, San Antonio (S.A.H., M.R.), Texas. sharrison@pinnacleresearch.com.
41Texas Tech University Health Science Center, Texas; 35. Tallahassee Memorial Hospital, Tallahassee, Florida. ialam@drimtiazalammd.com.
42Medical Affairs, Fibronostics, US Inc., Indian Harbour Beach, Florida . mona.munteanu@fibronostics.com.
43Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York. meena.bansal@mssm.edu.
44Barts Liver Centre, Blizard Institute, Queen Mary University of London, London. w.alazawi@qmul.ac.uk.
45Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia. arun.sanyal@vcuhealth.org.
Abstract
AIM: This study evaluates the diagnostic performance of the novel blood-based device, LIVERFASt to detect fibrosis stages in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), including those with type 2 diabetes (T2DM), compared to FIB-4 in a subgroup analysis.
METHODS: LIVERFASt is computed with 10 blood biomarkers and four anthropometric measures and provides a qua…
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