Microbiome and Heart Failure: A Comprehensive Review of Gut Health and Microbiota-Derived Metabolites in Heart Failure Progression.

Chukwudi Kingsley Orjichukwu¹, Rita Ogochukwu Orjichukwu², Peter Kanayochukwu Akpunonu³, Paul Chikwado Ugwu⁴, Somtochukwu Godfrey Nnabuife^5,6

¹Well Health Manitoba Clinic, 790 Sherbrook Street, Winnipeg MB R3A 1M4, Canada.

²Medway Maritime Hospital, Gillingham ME7 5NY, UK.

³North London NHS Foundation Trust, IT Department, 3rd Floor, West Wing, St. Pancras Hospital, 4 St. Pancras Way, London NW1 0PE, UK.

⁴King George Hospital, Barley Lane, Ilford IG3 8YB, UK.

⁵Cranfield University, Central Ave., Cranfield, Bedford MK43 0AL, UK.

⁶University of Wolverhampton, Wulfruna Street, Wolverhampton, West Midlands WV1 1LY, UK.

PubMed PMC DOI PDF

Abstract

A multifaceted clinical disease, heart failure (HF) is typified by decreased cardiac function and systemic symptoms caused by anatomical or functional abnormalities in the heart. Although traditional studies have concentrated on hemodynamic and neurohormonal processes, new data highlight the vital role that the gut microbiota and its byproducts play in the pathogenesis of HF. An imbalance in the m…

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