Peer-Reviewed Publication
J Biomed Opt2025;30(12):126007.December 1, 2025Clinical Study
Versatile and comprehensive hyperspectral imaging tool for molecular neuronavigation: a case study on cerebral gliomas.
Dorotea Nardini1,2, Anam Toaha1,2, Camilla Bonaudo3, Ivan Ezhov4, Angelos Artemiou5, Manuel Camelia3, Filippo Nozzoli6, Luca Giannoni5, Ilias Tachtsidis5, Alessandro Della Puppa3, Daniel Rueckert4,7,8, Pietro Ricci1,2, Francesco Pavone1,2,9
1University of Florence, Department of Physics and Astronomy, Sesto Fiorentino, Italy.
2European Laboratory for Non-linear Spectroscopy, Sesto Fiorentino, Italy.
3University of Florence, Azienda Ospedaliero-Universitaria Careggi, Neurosurgery, Department of Neuroscience, Psychology, Pharmacology and Child Health, Florence, Italy.
4Technischen Universität München, Klinikum rechts der Isar, Munich, Germany.
5University College London, Department of Medical Physics and Biomedical Engineering, London, United Kingdom.
6Careggi University Hospital, Histopathology and Molecular Diagnostics, Florence, Italy.
7Imperial College London, Department of Computing, London, United Kingdom.
8Munich Center for Machine Learning (MCML), Munich, Germany.
9National Institute of Optics, National Research Council, Florence, Italy.
Abstract
SIGNIFICANCE: Accurate and timely characterization of brain tumors remains a major challenge in neurosurgery. Current intraoperative guidance relies on preoperative imaging modalities such as magnetic resonance imaging, positron emission tomography, or computed tomography, which are essential for surgical planning but become less reliable during surgery due to brain shift. Furthermore, postoperati…
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