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Peer-Reviewed Publication
NPJ Digit Med2025;8(1):800.December 15, 2025Journal Article

A randomized clinical trial of app cognitive behavior therapy vs. HealthWatch for obsessive compulsive disorder.

Sabine Wilhelm1, Jennifer L Greenberg2, Ryan J Jacoby2, Hilary Weingarden2, Susanne S Hoeppner2, Dalton Klare2, Ivar Snorrason2, Adam C Jaroszewski2, Thomas H McCoy2, Oliver Harrison3
1Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. swilhelm@mgh.harvard.edu.
2Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
3Koa Health, London, UK.

Abstract

App-based cognitive behavioral therapy (app-CBT) addresses many treatment barriers. We randomized 120 U.S. adults with primary OCD (82.4% female, 77.5% White, mean age 40.1) between 7/2021 and 7/2023 to 12-weeks of coach-guided Perspectives (n = 60; app-CBT) or coach-guided HealthWatch (n = 60; an online well-being program). OCD severity (Yale-Brown Obsessive Compulsive Scale; primary outcome) ana…

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