Peer-Reviewed Publication
J Biophotonics2026;19(3):e202500374.March 1, 2026Journal Article
A Label-Free Hyperspectral Imaging Device for Ex Vivo Characterization and Grading of Meningioma Tissues.
Pietro Ricci1,2, Camilla Bonaudo3, Ivan Ezhov4, Anam Toaha1,2, Dorotea Nardini1,2, Manuel Camelia3, Federica Lucidi3, Filippo Nozzoli5, Tim Mach4, Ilias Tachtsidis6, Daniel Rueckert4,7,8, Alessandro Della Puppa3, Luca Giannoni6, Francesco S Pavone1,2,9
1Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy.
2European Laboratory for Non-Linear Spectroscopy, Sesto Fiorentino, Italy.
3Neurosurgery, Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
4Klinikum Rechts der Isar, Technischen Universität München, Munich, Germany.
5Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.
6Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
7Department of Computing, Imperial College London, London, UK.
8Munich Center for Machine Learning (MCML), Munich, Germany.
9National Institute of Optics, National Research Council, Sesto Fiorentino, Italy.
Abstract
Histopathology remains the gold standard for definitive tumor diagnosis after surgical resection; however, its lengthy processing time can delay critical postoperative care. Hyperspectral imaging (HSI) is emerging as a promising label-free technique for rapid biochemical tissue assessment. Here, we present HyperProbe1.1 (HP1.1), an HSI system designed for noninvasive analysis of fresh brain tumor…
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