Exploring copper metabolism and cuproptosis, and their implications in ocular diseases.

Xuanrui Xiong¹, Qiang Li², Yuanyuan Zhang³, Pan Liu⁴, Yuxu Pan⁵, Qiongtao Song⁶

¹Eye School of Chengdu University of TCM, No.37 Twelve Bridge Road, Chengdu, 610075, Sichuan, China.

²Eye School of Chengdu University of TCM, No.37 Twelve Bridge Road, Chengdu, 610075, Sichuan, China; Ineye Hospital of Chengdu University of TCM, No.8 Xinghui Road, Chengdu, 610084, Sichuan, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, No.37 Twelve Bridge Road, Chengdu, 610075, Sichuan, China; Guangzhou Ineye Vision Health Innovation Institute, No.2 Fenghuang 3rd Road, Guangzhou, 510555, Guangdong, China.

³Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, No.326 Xinshi South Road, Shijiazhuang, 050200, Hebei, China.

⁴Department of General Surgery, Chengdu First People's Hospital/Chengdu Integrated TCM & Western Medicine Hospital, No. 18, Wangxiang North Road, Chengdu, 610041, Sichuan, China.

⁵Sichuan Vocational College of Health and Rehabilitation, No.3 Deming Road, Zigong, 643030, Sichuan, China.

⁶Eye School of Chengdu University of TCM, No.37 Twelve Bridge Road, Chengdu, 610075, Sichuan, China; Ineye Hospital of Chengdu University of TCM, No.8 Xinghui Road, Chengdu, 610084, Sichuan, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, No.37 Twelve Bridge Road, Chengdu, 610075, Sichuan, China; Guangzhou Ineye Vision Health Innovation Institute, No.2 Fenghuang 3rd Road, Guangzhou, 510555, Guangdong, China. Electronic address: songqt607@cdutcm.edu.cn.

PubMed DOI

Abstract

Copper is a vital trace element for all living organisms and plays an important role in numerous physiological functions, including the formation of mitochondrial respiratory chain complexes, antioxidant defense, and signal transduction. However, excess copper can cause cellular toxicity and initiate a form of cell death that is characterized by the aggregation of lipoylated proteins and a reducti…

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